Status:
COMPLETED
Modulation of Cognitive Control Via Transcranial Continuous Electrical Stimulation of Additional Motor Areas in Parkinson's Patients
Lead Sponsor:
Assistance Publique Hopitaux De Marseille
Conditions:
Parkinson Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In Parkinson's disease (PD), recent work has shown that dopaminergic treatments alter one of the two aspects of impulsivity: they do not alter the propensity to produce "automatic" responses, but dete...
Eligibility Criteria
Inclusion
- Inclusion Criteria for Parkinsonien patients:
- Age\> 18 years old
- Idiopathic Parkinson's disease meeting the diagnostic criteria as defined by Ward and Gibb (1990)
- Patients usually taking dopaminergic treatment.
- No cognitive deterioration with: a Montreal Cognitive Assessment (MoCA) score ≥ 26
- Patient with Parkinson's disease in the advanced motor complications stage for which surgical treatment is being considered
- Inclusion Criteria for healthy subjects
- Age\> = 18 years old
- Patient free from Idiopathic Parkinson's Disease
- No cognitive deterioration: MMSE (MiniMentalSate Evaluation)\> 26
- Exclusion Criteria for both parkinsonien patients an healthy volunteers:
- Uncorrected altered visual acuity
- Dyschromatopsia (especially color blindness)
- Psychotropic treatment introduced or modified recently (\<1 month)
- Wearing a pacemaker (Pace Maker or Implantable Defibrillator)
- Pregnancy (verified by a urine pregnancy test for women of childbearing age)
- Other central nervous system disease (other parkinsonian syndrome, epilesia, stroke, etc.) or peripheral
- Intracranial metal implants on the cephalic stage and cochlear implant
- Untreated progressive mood or psycho-behavioral disorder
- Severe and poorly controlled eczema
- Exclusion criteria for Parkinson's patients only:
- Significant and disabling abnormal movement, not allowing good acquisition of the EMG signal (tremors or dyskinesias)
- Wearer of a Deep Brain Stimulation device (CI at tDCS).
Exclusion
Key Trial Info
Start Date :
June 2 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 16 2025
Estimated Enrollment :
67 Patients enrolled
Trial Details
Trial ID
NCT04897633
Start Date
June 2 2021
End Date
January 16 2025
Last Update
June 10 2025
Active Locations (1)
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1
Service Neurologie et pathologies du mouvement
Marseille, France, 13005