Status:
ENROLLING_BY_INVITATION
Eosinophils in Human Adipose Tissue
Lead Sponsor:
Mayo Clinic
Conditions:
Obesity
Insulin Resistance
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to better understand the interactions between the innate immune system, in particular eosinophils (EOS), and adipose tissue (AT) in human health and in disease states such...
Eligibility Criteria
Inclusion
- Obesity (BMI\>30 kg/m2).
- Evidence of insulin resistance as defined by hemoglobin A1c \> 5.7%.
- Mayo Clinic patients evaluated by Dr. Rahul Pannala.
- Pursue an endoscopic gastroplasty at Mayo Clinic Arizona in the Gastroenterology department.
- Equal distribution of gender.
- 18 yo older of age.
- BMI\>30 kg/m2.
- Nonsmoker.
- Taking no medication affecting glucose or lipid metabolism.
- No more than 5% change in body weight in the previous 6 months.
- Mostly sedentary (engaging in strenuous exercise (\> 70% max HR) less than 3 times a week).
- Not be receiving corticosteroid therapy.
- Have no history of asthma, COPD or atopic syndrome, or autoimmune disease (Ulcerative colitis, Chron's disease, eosinophilic esophagitis, any rheumatologic disease such as lupus, rheumatoid arthritis, Sjogren syndrome).
Exclusion
- \<17 years of age.
- BMI \<30 kg/m2.
- Smoker.
- Taking medication affecting glucose or lipid metabolism.
- Greater than 5% change in body weight within the previous six months.
- Engage in strenuous exercise (\>70% max HR) less than 3 times a week.
- Receiving corticosteroid therapy.
- Have a history of asthma.
- History of COPD or atopic syndrome.
- History of autoimmune disease (Ulcerative colitis, Chron's disease, eosinophilic esophagitis, any rheumatologic disease such as lupus, rheumatoid arthritis, Sjogren syndrome).
Key Trial Info
Start Date :
June 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT04898400
Start Date
June 1 2021
End Date
December 31 2025
Last Update
January 20 2025
Active Locations (1)
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1
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259