Status:
COMPLETED
Dietary Fructose on Microbiota and Hepatosteatosis
Lead Sponsor:
Shanghai Zhongshan Hospital
Collaborating Sponsors:
Fudan University
Conditions:
Hepatic Steatosis
Dietary Fructose Exposure
Eligibility:
MALE
18-40 years
Phase:
NA
Brief Summary
The consumption of sugar-sweetened beverages (SSB) has increased steadily over the past decades, resulting in the dramatic increase of fructose intake as it is one of the main ingredients of artificia...
Detailed Description
This is a single center, randomized, controlled study. 60 healthy men will be recruited according to the inclusion criteria. All subjects are randomly allocated to Group A and Group B, who orally take...
Eligibility Criteria
Inclusion
- Healthy men aged from 18 to 40 (including both ends);
- Body mass index (BMI) ranges from 18.5 to 23.9 kg/m2 (including both ends);
- The body weight has not changed dramatically in the past 3 months (±3kg);
Exclusion
- Subjects who have received antibiotic-related treatment, proton pump inhibitor treatment, or glucocorticoid hormone treatment within 1 month before enrollment;
- Subjects with diabetes or cardiovascular disease or other chronic diseases who require long-term medication;
- Subjects who suffered from an acute gastrointestinal diseases within the past month, or who have an history of chronic gastrointestinal disease or hepatitis;
- Subjects with a history of gastrointestinal surgery;
- Subjects with abnormal liver or kidney function, or severe cardiovascular diseases;
- Subjects with mental disorders or impaired cognitive function;
- Poor compliance;
- Participates enrolled in other clinical research at the same time;
- Other unsuitable occasions judged by clinicians..
Key Trial Info
Start Date :
June 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT04898621
Start Date
June 1 2021
End Date
December 31 2022
Last Update
June 7 2023
Active Locations (1)
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1
Department of Endocrinology, Zhongshan Hospital Fudan University
Shanghai, China