Status:
UNKNOWN
Orthostatic Intolerance and Hypotension After Administration of Morphine in Patients Prior to Hip or Knee Arthroplasty
Lead Sponsor:
Copenhagen University Hospital, Hvidovre
Collaborating Sponsors:
Kehlet, Henrik, M.D., Ph.D.
Conditions:
Orthostatic Hypotension
Orthostatic Intolerance
Eligibility:
All Genders
18+ years
Brief Summary
Incidence of orthostatic intolerance and orthostatic hypotension after intravenous administration of morphine in patients prior to hip or knee arthroplasty.
Detailed Description
Early postoperative mobilization is crucial for recovery of patients undergoing surgery in the multimodal fast-track approach to perioperative care, since physical immobilization is highly associated ...
Eligibility Criteria
Inclusion
- Patients undergoing primary unilateral total hip arthroplasty (THA), total knee arthroplasty (TKA) or unicompartmental knee arthroplasty (UKA)
- Patients \> 18
- Patients that understand and speak Danish
- Patients that have provided written informed consent
Exclusion
- Alcohol or substance abuse
- Habitual use of opioids
- Habitual use of anxiolytic, antidepressant and/or antipsychotic drugs
- History of previous orthostatic intolerance or hypotension
- Cognitive dysfunction
- Glomerular filtration rate (GFR) \< 30 ml/min
- Cardiac arrhythmia
Key Trial Info
Start Date :
April 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2022
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT04902222
Start Date
April 1 2021
End Date
May 1 2022
Last Update
June 18 2021
Active Locations (1)
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1
Hvidovre University Hospital
Hvidovre, Denmark, 2960