Status:
COMPLETED
Absorption and Safety of Topical Timolol to Treat Chronic Wounds
Lead Sponsor:
VA Northern California Health Care System
Conditions:
Glaucoma, Open-Angle
Chronic Wounds
Eligibility:
All Genders
18+ years
Brief Summary
Topical timolol has been used primarily as eye drops to treat glaucoma for many years. Recent clinical experience has broadened its off-label use for a number of skin conditions, including slow-healin...
Detailed Description
Chronic wounds, such as diabetic foot ulcers, venous leg ulcers and pressure ulcers are serious problems in our health system, with limited therapeutic options available to improve healing. Our labora...
Eligibility Criteria
Inclusion
- Over 18 years of age
- Using physician-prescribed timolol as directed
- The ability to read, understand, and sign informed consent for blood draw and release of medical information forms
- For wound group: documented chronic wound (greater than 30 days, with minimal improvement), with any type of wound.
- For glaucoma group: diagnosed with ocular hypertension or open-angle glaucoma.
Exclusion
- Patient is not currently prescribed timolol or currently taking oral metoprolol
- History of any type of heart block
- History of bradycardia (heart-rate less than 60 beats per minute (bpm))
- History of documented hypotension
- History of asthma or chronic obstructive pulmonary disease.
Key Trial Info
Start Date :
November 21 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 14 2020
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04903366
Start Date
November 21 2017
End Date
January 14 2020
Last Update
May 27 2021
Active Locations (1)
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1
VA Northern California Health Care System
Mather, California, United States, 95655