Status:
RECRUITING
Study on Early Genetic Screening and Precise Strategy of Neonatal Critical Illness
Lead Sponsor:
Children's Hospital of Fudan University
Collaborating Sponsors:
International Peace Maternity and Child Health Hospital
Obstetrics & Gynecology Hospital of Fudan University
Conditions:
Genetic Screening
Hereditary Disease
Eligibility:
All Genders
Up to 100 years
Brief Summary
The researchers hope to establish an overall program of early genetic screening for neonatal critical illness in China, and to develop precise intervention strategies to assist clinical diagnosis and ...
Detailed Description
Reducing the rate of neonatal death and disability is an important part of health education in China, and genetic diseases are an important cause of neonatal death. At present, with the development of...
Eligibility Criteria
Inclusion
- Postnatal age less than 100 days;
- Perinatal death after 20 weeks of gestation (more than 500 g)
- Can be retained biological samples for genetic screening;
- Biological parent or guardian's informed consent.
Exclusion
- Reluctance of parents to use genetic sequencing data for subsequent research;
- Parents under 18 years of age or incapacitated for decision-making;
- subjects older than 100 days;
- Perinatal death less than 20 weeks of gestation or weight less than 500 g;
- Inherited metabolic diseases with chromosomal abnormalities;
- Multiple pregnancies;
- Lack of access to biological samples from which DNA can be extracted;
- Failure to sign informed consent.
Key Trial Info
Start Date :
January 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
4000 Patients enrolled
Trial Details
Trial ID
NCT04905537
Start Date
January 1 2021
End Date
December 1 2025
Last Update
February 20 2025
Active Locations (1)
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1
Children's Hospital of Fudan University
Shanghai, Shanghai Municipality, China