Status:
COMPLETED
Single Dose Pharmacokinetic Study of GB221 in Comparison With Herceptin ®
Lead Sponsor:
Genor Biopharma Co., Ltd.
Conditions:
Breast Cancer
Eligibility:
All Genders
18-45 years
Phase:
PHASE1
Brief Summary
This is a single center, randomized, blind, parallel controlled clinical trial. The primary objective is to evaluate the single dose pharmacokinetics of recombinant Humanized anti-HER-2 monoclonal ant...
Detailed Description
Subjects will enroll in random order, and be divided into two groups, then receive a single dose (6 mg/kg) of GB221 or Herceptin ®, and accept observation for 42 days. Throughout the course, safety da...
Eligibility Criteria
Inclusion
- 1\. Signed informed consent form;
- 2\. Healthy adult volunteers aged between 18 and 45, male or female;
- 3\. Medical examination as required within 28 days, body mass index (BMI) 19.0 \~ 24.0, weight≥50 kg for men, ≥45 kg for women, and≤ 75 kg for both;
- 4\. Agreed with taking reliable contraceptive measures, and no fertility planning from the beginning to the end of the study within 6 months;
- Subject can communicate well with the investigators and complete the study according to the study regulations.
Exclusion
- 1\. Pregnant or lactating women, or positive in either blood or urine pregnancy test; or unwilling to take effective contraceptive measures during the trial and within 6 months after the end of the trial at fertile age;
- 2\. Allergic constitution; or history of allergic to experimental drug ingredient or any drug or food or pollen; or abnormal serum immunoglobulin E (IgE) test;
- 3\. History of drug abuse, or positive urine test for drug;
- 4\. History of the central nervous system, cardiovascular system, kidney, liver, digestive system, respiratory system, metabolic system or other significant diseases. History of high blood pressure, or clinically significant systolic blood pressure≥140 mmHg/diastolic blood pressure≥90 mmHg;
- 5\. Family history of cancer, or tumor markers (male: CEA, AFP, PSA, CA-125; Female: CEA, AFP, CA-153, CA-125) positive.
- 6\. Participated in other clinical trials of drug or used drugs harmful to major organs within 3 months;
- 7\. Blood donation within 3 months;
- 8\. Used prescription or OTC drugs within 14 days;
- 9\. Left ventricular ejection fraction (LVEF) \< 60%;
- 10\. ALT or AST \> 1.5 ULN, Cr \> ULN;
- 11\. WBC \< 0.8 LLN or \> 1.2 ULN; ANC \< 0.8 LLN; PLT \< 0.8 LLN; HGB \< 0.9LLN.
- 12\. HBs-Ag, HCV-Ab, anti-HIV or TP-Ab positive;
- 13\. Anti-drug antibody (ADA) test positive;
- History of psychosis;
- 15\. History of postural hypotension;
- 16\. More than 5 cigarettes per day;
- 17\. More than 28 units of alcohol per week; Or alcohol breath test positive within 24 hours before pre-dose;
- 18\. History of dizziness of blood or needle;
- 19\. Unsuitable for other reasons.
Key Trial Info
Start Date :
November 13 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 11 2020
Estimated Enrollment :
87 Patients enrolled
Trial Details
Trial ID
NCT04905667
Start Date
November 13 2019
End Date
September 11 2020
Last Update
May 27 2021
Active Locations (1)
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1
The Fifth Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangzhou, China, 510799