Status:
COMPLETED
RNF213 Variants and Collateral Vessels in Moyamoya Disease
Lead Sponsor:
Beijing Tiantan Hospital
Conditions:
Moyamoya Disease
Eligibility:
All Genders
4-60 years
Brief Summary
The purpose of this study is to detect the association between RNF213 variants and collateral vessels in patients with moyamoya disease.
Detailed Description
Moyamoya disease (MMD) is a chronic cerebrovascular disorder characterized by the presence of occlusion which occurs at the internal carotid arteries and their main branches during the development of ...
Eligibility Criteria
Inclusion
- Written informed consent is obtained
- Patients with age between 4-60 years
- Cerebral digital subtraction contrast angiography (DSA) reveal severe stenosis or occlusion of the distal internal carotid or proximal middle and anterior cerebral arteries with prominent lenticulostriate 'moyamoya collaterals'
Exclusion
- There are other vascular diseases, including systemic vasculitis, neurofibroma, meningitis, sickle cell disease, down's syndrome, and previous basilar radiotherapy
- Patients with cardiogenic embolism, including a history of atrial fibrillation, valvular disease or cardiac valve replacement
- Physical or subjective failure to cooperate with the examination or serious comorbid diseases
Key Trial Info
Start Date :
January 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 30 2021
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT04906564
Start Date
January 1 2019
End Date
June 30 2021
Last Update
February 17 2022
Active Locations (1)
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1
Beijing Tiantan Hospital Capital Medical University
Beijing, Beijing Municipality, China