Status:
UNKNOWN
Cetuximab Sensitivity Correlation Between Patient-Derived Organoids and Clinical Response in Colon Cancer Patients.
Lead Sponsor:
D1 Medical Technology (Shanghai) Co., Ltd, China
Collaborating Sponsors:
Fudan University
Conditions:
Colon Cancer
Organoids
Eligibility:
All Genders
18-70 years
Brief Summary
Eighty patients with RAS/RAF wild-type metastatic right colon cancer will be enrolled and undergo a fresh biopsy of tumor lesion before the standard treatment of chemotherapy. The investigators will e...
Detailed Description
Investigators hypothesize that the cetuximab sensitivity test results on patient-derived organoids can be used to predict the treatment selection of patients with RAS/RAF wild-type metastatic right co...
Eligibility Criteria
Inclusion
- Age from 18 to 70 years old, no gender limit
- The primary tumor is located in the right colon, including the ileocecal area, ascending colon, liver flexure, and the right part of the transverse colon.
- Pathologically proved primary intestinal tumor with simultaneous / metachronous metastasis
- Molecular pathology confirmed as RAS/RAF wild type
- Can tolerate and cooperate with the completion of chemotherapy and targeted therapy
- Tissues can be obtained through puncture or colonoscopy for organoid culture
- Complete clinical data, as well as efficacy evaluation data, can be obtained
Exclusion
- Less than 18 years of age or more than 70 years of age
- The primary tumor is located in the left colon or rectum
- Pathology results can't confirm as colon cancer
- RAS and RAF are mutant confirmed by molecular pathology
- Refuse to cooperate and complete the treatment, or there is a contraindication for chemotherapy or targeted therapy
- No available metastatic lesions tissue
- Unable to obtain complete clinical data or efficacy evaluation data
Key Trial Info
Start Date :
April 15 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2023
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04906733
Start Date
April 15 2021
End Date
December 1 2023
Last Update
August 13 2021
Active Locations (1)
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1
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China, 200032