Status:
COMPLETED
Diagnostic and Prognostic Accuracy of Gold Nanoparticles in Salivary Gland Tumours
Lead Sponsor:
Amina Fouad Farag
Conditions:
Carcinoma Ex Pleomorphic Adenoma of Salivary Glands
Pleomorphic Adenoma of Salivary Glands
Eligibility:
All Genders
Brief Summary
Nano-based diagnostic tool can provide promising highly sensitive, specific biomarker for early detection and treatment of salivary gland tumours compared to non-conjugated biomarkers and in turn impr...
Detailed Description
Cancer stem cells form a small subset of highly tumorigenic cells within the bulk of the tumours which mainly responsible for initiation, invasion, rapid growth, metastasis and therapeutic resistance ...
Eligibility Criteria
Inclusion
- Benign PA of major and minor salivary glands (PA group),
- CXPA of major and minor salivary glands (CXPA group).
- Border of excision biopsy of mucocele in the lip mucosa of healthy individuals used as normal controls (Control group).
- Surgical excision of tumors with no preoperative chemotherapy or radiotherapy. For parotid tumours partial or total parotidectomy, Surgery was performed with or without facial nerve preservation and the later was carried out commonly when the nerve was involved by tumour. For tumours in the other glands, complete surgical excision with the involved gland and the suspicious adjacent structures was performed.
Exclusion
- All epithelial origin salivary gland tumours other than PA and CXPA.
- All mesenchymal origin salivary gland tumours.
- All inflammatory and cystic lesions of salivary glands.
- Metastasis in salivary glands.
- Patients received preoperative chemotherapy or radiotherapy.
Key Trial Info
Start Date :
August 6 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 3 2021
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04907422
Start Date
August 6 2018
End Date
February 3 2021
Last Update
September 1 2021
Active Locations (1)
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1
Faculty of Dentistry, October 6 University
Giza, Egypt, 12511