Status:
COMPLETED
A Study of an Adenovirus Serotype 26 Pre-fusion Conformation-stabilized F Protein (Ad26. RSV. preF) Based Respiratory Syncytial Virus (RSV) Vaccine in the Prevention of Lower Respiratory Tract Disease in Adults Aged 60 Years and Older
Lead Sponsor:
Janssen Vaccines & Prevention B.V.
Conditions:
Respiratory Syncytial Viruses
Lower Respiratory Tract Disease
Eligibility:
All Genders
60+ years
Phase:
PHASE3
Brief Summary
The study will enroll up to 27,200 participants in order to demonstrate the efficacy of the active Ad26.RSV.preF-based study vaccine in the prevention of Reverse Transcription Polymerase Chain Reactio...
Eligibility Criteria
Inclusion
- Must be able to work with smartphones/tablets/computers
- From the time of vaccination through 3 months after vaccination, participant agrees not to donate blood
- Must be willing to provide verifiable identification, has means to be contacted and to contact the investigator during the study
- Before randomization, a participant must be: a. postmenopausal (postmenopausal state is defined as no menses for 12 months without an alternative medical cause); and b. not intending to conceive by any methods
- Participants must sign an Inform Consent Form (ICF) indicating that the participant understands the purpose, procedures and potential risks and benefits of the study, and is willing to participate in the study
Exclusion
- Has a serious clinically unstable condition, (example, end-stage renal disease with or without dialysis, clinically unstable cardiac disease), Alzheimer's disease, or any other condition for which, in the opinion of the investigator, participation would not be in the best interest of the participant (example, compromise well-being) or that could prevent, confound, or limit the protocol specified assessments
- History of malignancy within 5 years before screening not in the following categories: a. Participants with squamous and basal cell carcinomas of the skin and carcinoma in situ of the cervix may be enrolled at the discretion of the investigator; b. Participants with a history of malignancy within 5 years, which is considered cured with minimal risk of recurrence per investigator's judgement, can be enrolled
- Had major surgery (example, major cardiopulmonary or abdominal operations) as per the investigator's judgment within 4 weeks before vaccination, or will not have fully recovered from surgery, or has major surgery planned during the time the participant is expected to participate in the study
- Employee of the investigator or study site, with direct involvement in the proposed study or other studies under the direction of that investigator or study site, as well as family members of the employees or the investigator, or an employee of the sponsor
- Contraindication to Intramuscular (IM) injections and blood draws (example, bleeding disorders)
- Known or suspected allergy or history of anaphylaxis or other serious adverse reactions to vaccines or vaccine components (including any of the constituents of the study vaccine)
Key Trial Info
Start Date :
July 21 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 21 2023
Estimated Enrollment :
25236 Patients enrolled
Trial Details
Trial ID
NCT04908683
Start Date
July 21 2021
End Date
July 21 2023
Last Update
November 13 2025
Active Locations (272)
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1
Central Research Associates, Inc.
Birmingham, Alabama, United States, 35205
2
Synexus Clinical Research US Inc
Birmingham, Alabama, United States, 35211
3
Achieve Clinical Research, LLC
Birmingham, Alabama, United States, 35216
4
Optimal Research
Huntsville, Alabama, United States, 35802