Status:
TERMINATED
Osimertinib and Locally Ablative Radiotherapy in Patients With Synchronous Oligo-metastatic EGFR Mutant NSCLC (STEREO)
Lead Sponsor:
ETOP IBCSG Partners Foundation
Collaborating Sponsors:
AstraZeneca
Conditions:
NSCLC Stage IV
EGFR Gene Mutation
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
STEREO is single-arm phase II study, which aims to evaluate the safety and efficacy of osimertinib combined with early locally ablative radiotherapy of all cancer sites in patients with synchronous ol...
Detailed Description
Targeting Epidermal Growth Factor Receptor (EGFR) mutation has fundamentally changed the treatment of metastatic Non-Small Cell Lung Carcinoma (NSCLC). Several randomised phase III studies have compa...
Eligibility Criteria
Inclusion
- Histologically confirmed, treatment naïve EGFR-mutant NSCLC, with or without T790M resistance mutation. Presence of the sensitising EGFR-mutation (exon 19 deletion and/or exon 21 L858R) detected by an accredited laboratory.
- Synchronous oligo-metastatic stage IV disease (max 5 lesions)
- Measurable disease as defined according to RECIST v1.1
- All lesions amenable for radical radiotherapy according to local judgment
- Age ≥18 years
- ECOG performance status 0-2
- Life expectancy ≥12 months
- Adequate haematological, renal \& liver function
- Women of childbearing potential, including women who had their last menstruation in the last 2 years, must have a negative urinary or serum pregnancy test within 7 days before enrolment.
- Written IC for protocol treatment
Exclusion
- Prior chemotherapy, immunotherapy, radiotherapy or therapeutical surgery for NSCLC (an exception is the resection and postoperative radiotherapy of the resection cavity of CNS or adrenal metastases)
- More than 5 distant oligo-metastases (any second intra-thoracic lesion will count as a distant metastasis; regional nodal metastases will not count towards 5 oligo-metastases) and more than 2 intra-thoracic lesions.
- Brain metastases not amenable for radiosurgery or neurosurgery
- Presence of leptomeningeal metastases
- Symptomatic spinal cord compression
- Extracranial metastatic locations not amenable for radical radiotherapy
- Currently receiving medications or herbal supplements known to be potent CYP3A4 inducers
- Any evidence of severe or uncontrolled systemic diseases
- Refractory nausea and vomiting, chronic gastrointestinal diseases, inability to swallow the formulated product or previous significant bowel resection that would preclude adequate absorption of osimertinib
- Any of the following cardiac criteria: QTcF \>470 msec; Any clinically important abnormalities in rhythm, conduction or morphology of resting ECG; Any factors that increase the risk of QTc prolongation or risk of arrhythmic events
- Past medical history of Interstitial Lung Disease (ILD), drug-induced ILD, radiation pneumonitis which required steroid treatment, or any evidence of clinically active ILD
- Idiopathic pulmonary fibrosis which is a contraindication to lung radiation.
- History of hypersensitivity to active or inactive excipients of osimertinib or drugs with a similar chemical structure or class to osimertinib.
- Judgment by the investigator that the patient should not participate in the study if the patient is unlikely to comply with study procedures, restrictions and requirements
- Women who are pregnant or in the period of lactation.
- Sexually active men and women of childbearing potential who are not willing to use an effective contraceptive method during the trial and up to 6 weeks for women and up to 4 months for men, after the last osimertinib dose.
Key Trial Info
Start Date :
August 4 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 29 2024
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT04908956
Start Date
August 4 2022
End Date
February 29 2024
Last Update
June 28 2024
Active Locations (18)
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1
IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)
Meldola, Italy, 47014
2
Instituto Europeo di Oncologia (IEO)
Milan, Italy
3
AULSS2 Marca Trevigiana Treviso
Treviso, Italy
4
The Netherlands Cancer Institute Amsterdam
Amsterdam, Netherlands, 1006 BE