Status:
ACTIVE_NOT_RECRUITING
APOL1 Genetic Testing Program for Living Donors
Lead Sponsor:
Northwestern University
Collaborating Sponsors:
Georgetown University
Conditions:
Chronic Kidney Diseases
Apolipoprotein L1
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Living donor (LD) kidney transplantation is the optimal treatment for patients with end-stage kidney disease (ESKD). However, LDs take on a higher risk of future ESKD themselves. African American (AA)...
Detailed Description
This project, "Integrating a culturally competent APOL1 genetic testing program into living donor evaluation," will integrate APOL1 testing into the evaluation of living kidney donor candidates of Afr...
Eligibility Criteria
Inclusion
- Living kidney donor candidates who identify as African American/Black, Jamaican, Barbadian, Grenadian, Brazilian from Salvador Trinidadian, Panamanian, Honduran, Haitian, Garifunan, Palenque, Guyanese, Dominican, Peruvian, Belizean, and Native American, or state that they have African ancestry or are aware of having biologically-related family with African ancestry
- Living kidney donor candidates may be directed or non-directed donors
- Adults (ages 18+)
- English-speaking
- Cognitively intact individuals
- All genders
Exclusion
- Individuals who do not identify as African American/Black and are not aware of having any biologically-related family with African ancestry and do not have African ancestry
- Only African Americans and people of African ancestry will be included because APOL1 risk variants are predominantly found in African Americans and people who have African ancestry.
- Pregnant women cannot be living kidney donors
Key Trial Info
Start Date :
September 9 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 31 2026
Estimated Enrollment :
206 Patients enrolled
Trial Details
Trial ID
NCT04910867
Start Date
September 9 2021
End Date
March 31 2026
Last Update
July 25 2025
Active Locations (2)
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1
Medstar Georgetown Transplant Institute
Washington D.C., District of Columbia, United States, 20007
2
Northwestern University Feinberg School of Medicine
Chicago, Illinois, United States, 60611