Status:
COMPLETED
Iron and Vaccine Response
Lead Sponsor:
Swiss Federal Institute of Technology
Collaborating Sponsors:
Jomo Kenyatta University of Agriculture and Technology
Conditions:
Iron Deficiency Anemia
Vaccine Preventable Disease
Eligibility:
FEMALE
18-55 years
Phase:
NA
Brief Summary
Vaccines often underperform in Africa compared to high-income countries. Why vaccines do not work as well in Africa remains uncertain. Malnutrition likely plays a role. Our study objective is to asses...
Detailed Description
Group 1 (immediate iron treatment) will receive iron treatment before vaccination. Women in both groups will receive two intramuscular vaccines (influenza and yellow fever). Vaccine response will be m...
Eligibility Criteria
Inclusion
- 18-55 years old
- Zinc protoporphyrin \> or equal 40 mmol/mol heme
- hemoglobin \< or equal 109 g/L
- no malaria
- no known HIV infection
- no medical condition that precludes study involvement
- no iron supplementation 1 week prior to study start
- no recent tuberculosis infection
- no vaccination of yellow fever or influenza prior to enrolment
- not pregnant
Exclusion
- \-
Key Trial Info
Start Date :
May 29 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 9 2021
Estimated Enrollment :
121 Patients enrolled
Trial Details
Trial ID
NCT04912661
Start Date
May 29 2021
End Date
September 9 2021
Last Update
September 14 2021
Active Locations (1)
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1
Msambweni County Referral Hospital
Msambweni, Kwale County, Kenya