Status:
COMPLETED
Dystonia Treatment With Injections Supplemented By Transcranial Magnetic Stimulation
Lead Sponsor:
University of Florida
Collaborating Sponsors:
Dystonia Medical Research Foundation
Conditions:
Cervical Dystonia
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
We applied 16 sessions of rTMS over 4 consecutive days for adult patients suffering from cervical dystonia who received botulinum toxin (BoNT) injections on a regular basis. The TMS protocol took plac...
Detailed Description
This was a crossover study design in which patients were randomized to active or sham stimulation during session 1 (S1) and then crossed over to the condition they were not randomized to at first duri...
Eligibility Criteria
Inclusion
- patients 18-85 years of age who receive regular botulinum toxin (BoNT) scheduled every 12 weeks, on stable optimized doses but with reported benefits lasting ≤ 9 weeks for 2 consecutive cycles. Patents followed at our center routinely fill out a self-reported form to document the duration of benefits perceived with BoNT therapy. Participants will be allowed to continue oral medications that they are taking for dystonia concurrently but will not be allowed to change their concurrent medication regimen throughout the duration of the study.
Exclusion
- Presence of metallic objects or neurostimulators in the brain
- Pregnancy
- History of active seizures or epilepsy
- Patients with severe scoliosis or other gait impairment that will preclude them from participating in gait evaluation.
Key Trial Info
Start Date :
February 7 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 7 2024
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT04916444
Start Date
February 7 2022
End Date
January 7 2024
Last Update
October 8 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Florida Health Norman Fixel Institute for Neurological Diseases
Gainesville, Florida, United States, 32608