Status:
RECRUITING
Neurobiological and Psychological Maintenance Mechanisms Associated With Anticipatory Reward in Bulimia Nervosa
Lead Sponsor:
University of Minnesota
Conditions:
Bulimia Nervosa
Eligibility:
All Genders
18-55 years
Brief Summary
The purpose of this investigation is to identify the potentially crucial role of anticipatory reward mechanisms maintaining bulimic behavior (i.e., binge eating and purging) in bulimia nervosa (BN). T...
Detailed Description
Bulimia nervosa (BN), an eating disorder characterized by recurrent bulimic episodes of binge eating and often persists in spite of treatment, likely indicating ineffectively targeted maintenance mech...
Eligibility Criteria
Inclusion
- Bulimia nervosa (BN) and healthy control (HC) groups:
- Right-handed
- Ability to read and speak in English
- BN group only:
- Eating Disorder Examination (EDE) diagnosis of BN (i.e., at least one objective bulimic episode and one self-induced vomiting episode per week for at three months) with binge episodes always accompanied by self-induced vomiting
- Stable dose for at least 6 weeks of any recent changes in medication impacting mood, appetite, or weight
- HC group only:
- No binge eating or purging episodes for the past three months on the EDE
- No current or past history of an eating disorder as diagnosed by Structured Clinical Interview for DSM-5 Disorders
Exclusion
- History of gastric bypass surgery
- Medical condition acutely affecting eating behavior and/or weight (i.e., pregnancy, lactation, thyroid disease)
- Current medical or psychiatric instability (i.e., hospitalization required in the past three months)
- Lifetime history of psychosis or bipolar disorder
- History of neurological disorder or injury (i.e., stoke, head injury with \>10 minutes loss of consciousness)
- Current substance use disorder
- BMI less than 19 kg/m\^2
- Acute suicidality requiring hospitalization
- fMRI exclusions as specifiedd by the Center for Magnetic Resonance Research
- Food allergy that cannot be accommodated through substitutions to the laboratory test snack
Key Trial Info
Start Date :
April 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 30 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04917068
Start Date
April 1 2022
End Date
November 30 2026
Last Update
January 8 2026
Active Locations (1)
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1
University of Minnesota
Minneapolis, Minnesota, United States, 55455