Status:
UNKNOWN
EEG and TMS-based Biomarkers of ALS, MS and FTD
Lead Sponsor:
University of Dublin, Trinity College
Collaborating Sponsors:
Motor Neurone Disease Association, UK
Irish Research Council, IE
Conditions:
Amyotrophic Lateral Sclerosis
Frontotemporal Dementia
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this observational study is to improve understanding of the biology of why ALS, MS and FTD have different effects on different people and facilitate better measurement of the disease in...
Detailed Description
The aim of this project is to characterize spatiotemporal patterns of central nervous system dysfunction that correlate with clinical features of ALS, MS and FTD, to provide non-invasive electrophysio...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Age \>18 years and able to give informed written or verbal (in the presence of two witnesses) consent.
- In the case of non-control subjects, a clinical diagnosis of:
- (i) Probable frontotemporal dementia (FTD) including behavioural variant FTD, semantic dementia or primary progressive aphasia) with supportive brain imaging or known FTD causing genetic mutation (ii) Multiple sclerosis (MS) according to the McDonald criteria (Polman et al., 2011) or (iii) Possible, probable or definite amyotrophic lateral sclerosis (ALS) according to the El Escorial Criteria Revised (Brooks et al. 2000)
- Exclusion criteria:
- Any diagnosed neurological/muscular disease other than ALS, MS or FTD
- Use of neuro- or myo-modulatory medications except riluzole
- Inability to participate due to disease-related motor symptoms (e.g. inability to sit for the required time or click the mouse to respond)
- Upper body metallic implants
- History of seizure disorders in the participant or immediate family members
- Anxiety-induced fainting
- Regular migraine
- Evidence of significant respiratory insufficiency
- Sleep time \>2 hours below normal and/or alcohol consumption the night before data collection (in which case, recording session will be rescheduled).
Exclusion
Key Trial Info
Start Date :
September 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2023
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT04918251
Start Date
September 1 2012
End Date
April 1 2023
Last Update
June 8 2021
Active Locations (1)
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1
Academic Unit of Neurology, Trinity College Dublin, The University of Dublin
Dublin, Leinster, Ireland, Dublin 2