Status:
COMPLETED
Low Dose Continuous Furosemide Effect on Cardiac Surgery Patients With Kidney Dysfunction
Lead Sponsor:
National Cardiovascular Center Harapan Kita Hospital Indonesia
Conditions:
Chronic Kidney Disease
Cardiac Disease
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
Chronic kidney disease is an independent risk factor for cardiovascular disease associated with increased mortality rate during cardiac surgery in proportion to the kidney function. Chronic kidney dis...
Detailed Description
The study was a double-blind randomized controlled trial to determine the protective effect of low-dose continuous furosemide perioperative in cardiac surgery patients with mild to moderate kidney dys...
Eligibility Criteria
Inclusion
- Age 18 to 65 years old.
- Patient planned with elective cardiac surgery such as CABG, one cardiac valve replacement, one cardiac valve repair or two valves, CABG and replacement/repair one cardiac valve.
- Cardiac surgery performed using cardiopulmonary bypass machine.
- Patient with mild to moderate kidney dysfunction (GFR 30-89 mL/min/1.73m2) and never got renal replacement therapy before.
Exclusion
- Cardiac ejection fraction \<40%.
- Patient with new preoperative acute renal failure by any cause.
- Sudden shift in cardiac surgery timing (emergency cardiac surgery or repeated procedure).
- Complex cardiac disease associated with intra aortic balloon pump use, replacement of more than two cardiac valves, coronary artery disease with severe valve disease, and patient with pulmonary hypertension, and cardiac surgery procedures for congenital heart disease.
- Patient with aortic abnormality, and/or has direct effect on renal artery.
- Patients concurrently enrolled in other study with other drugs being studied.
- Patient with hemodynamic disturbance caused by hemorrhage, sepsis, anaphylactic, or cardiogenic shock.
- Patient refuses to participate in the study.
Key Trial Info
Start Date :
May 27 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 28 2022
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT04919564
Start Date
May 27 2021
End Date
February 28 2022
Last Update
January 5 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
National Cardiovascular Center Harapan Kita Jakarta
Jakarta, Indonesia, 11420