Status:
RECRUITING
Efficacy and Safety of Hemoperfusion With Polymyxin B in Septic Shock Associated With Severe Endotoxemia in Cardiac Surgery Patients (РМХ vs SS)
Lead Sponsor:
Petrovsky National Research Centre of Surgery
Conditions:
Multiple Organ Dysfunction With Severe Endotoxemia
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Sepsis is a state of multiple organ dysfunction caused by a generalized immune-inflammatory response of the body to an infectious agent, with pronounced heterogeneity and interchangeability of clinica...
Detailed Description
PMX versus SS (polymyxin B versus septic shock) is a single-center, historic, randomized clinical trial to investigate the safety and efficacy of polymyxin B columns (PMX 20R, Toray) in adult patients...
Eligibility Criteria
Inclusion
- SOFA +2 points in comparison with the previous assessment; РСТ more than 2 ng / ml; CRP more than 150 ng / ml; norepinephrine infusion; intestinal paresis; positive data of blood culture; ЕАА more than 0,6
Exclusion
- bleeding; heparin-induced thrombocytopenia
Key Trial Info
Start Date :
November 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04920565
Start Date
November 1 2021
End Date
December 1 2025
Last Update
November 25 2024
Active Locations (1)
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1
Petrovsky National Reasearch Centre of Surgery
Moscow, Russia, 119991