Status:
COMPLETED
Repurposing of Dextromethorphan as an Adjunct Therapy in Patients With Major Depressive Disorder
Lead Sponsor:
All India Institute of Medical Sciences, Bhubaneswar
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
Therapeutic latency, lack of efficacy, and adverse drug reactions are the major concerns in current antidepressant therapies. One-third of the patients with major depressive disorder do not respond to...
Detailed Description
Major depressive disorder (MDD) is a common psychiatric disorder with a substantial socioeconomic burden with a global prevalence rate of 16%. The underlying pathophysiology of depression is still not...
Eligibility Criteria
Inclusion
- Patients diagnosed with major depressive disorder of either gender within the age group of 18-65 years
- Patients with MADRS score ≥ 7 and ≤ 34 (patients having mild to moderate MDD).
- Patients who are on a stable dose of Sertraline 50 mg or any other Selective Serotonin Reuptake Inhibitor (SSRI) therapy in equivalent dose for less than equal to 4 weeks.
- Patients who have given written informed consent.
Exclusion
- Patients who have been treated with Electro Convulsive Therapy (ECT) recently.
- History of epilepsy, or other major neurological or medical disorders, head trauma.
- Patients with a history of Bipolar Depression (BPD).
- Patients with schizophrenia or other psychotic disorder.
- Patients with suicidal thoughts or risk.
- Patients with cognitive impairment.
- Initiating or stopping formal psychotherapy within six weeks before enrolment.
- Patients with comorbidities like any malignancies, hepatic, renal, cardiovascular,
- neurological or endocrinal, respiratory dysfunction.
- Substance abuse history of psychoactive agents.
- Pregnant and lactating mothers.
Key Trial Info
Start Date :
February 10 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 30 2023
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05181527
Start Date
February 10 2022
End Date
November 30 2023
Last Update
December 22 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
All India Institute of Medical Sciences (AIIMS)
Bhubaneswar, Odisha, India, 751019