Status:
RECRUITING
Autologous Platelet Rich Plasma Intraovarian Infusion for Poor Responders
Lead Sponsor:
Genesis Athens Clinic
Collaborating Sponsors:
National and Kapodistrian University of Athens
Conditions:
Poor Response to Ovulation Induction
Infertility, Female
Eligibility:
FEMALE
35-47 years
Phase:
PHASE2
PHASE3
Brief Summary
Autologous platelet rich plasma (PRP) intraovarian infusion may improve ovarian response to controlled ovarian stimulation as well as the hormonal profile of poor ovarian response infertile women subj...
Detailed Description
Despite recent advances in reproductive medicine, poor ovarian response (POR) management is still considered to be very challenging. Commonly, POR patients present with reduced ovarian reserve and poo...
Eligibility Criteria
Inclusion
- Poor Ovarian Response according to Bologna Criteria (fulfilling 2 out of 3 of the following):
- Age ≥ 40 years
- AMH \< 1.1 ng/ml OR AFC \< 7
- ≤ 3 oocytes with a conventional stimulation protocol
- Discontinuation of any complementary/adjuvant treatment including hormone replacement and acupuncture, for at least three months prior to recruitment.
- Willing to comply with study requirements
Exclusion
- Any pathological disorder related to reproductive system anatomy
- Cycle irregularities
- Amenorrhea
- Endometriosis
- Adenomyosis
- Fibroids and adhesions
- Infections in reproductive system
- Current or previous diagnosis of cancer in reproductive system
- History of familiar cancer in reproductive system
- Severe male factor infertility
- Prior referral for Preimplantation Genetic Testing (PGT) -Ovarian inaccessibility -Endocrinological disorders (Hypothalamus-
- Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome)
- BMI\>30 kg/m2 or BMI\<18.5 kg/m2
- Systematic autoimmune disorders
Key Trial Info
Start Date :
January 23 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 31 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT05181748
Start Date
January 23 2019
End Date
January 31 2026
Last Update
December 27 2024
Active Locations (1)
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1
Genesis Athens Clinic
Athens, Attica, Greece, 15232