Status:
COMPLETED
Early Feasibility Study of Somatostatin Receptors PET Imaging for the Diagnosis of Infective Endocarditis
Lead Sponsor:
Central Hospital, Nancy, France
Conditions:
Infective Endocarditis
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Study hypothesis: 68Ga-DOTATOC PET/CT could detect cardiac foci of infective endocarditis regardless of the type of valve (native or prosthetic) and also extracardiac localizations related to this pat...
Detailed Description
The incidence of infective endocarditis (IE) in France is estimated to be around 30 cases per million inhabitants in studies conducted in Western countries and is significantly increased in patients w...
Eligibility Criteria
Inclusion
- Adult who has received full information about the organisation of the research and has signed informed consent adult
- Participant hospitalised for definite AE according to modified Duke criteria (Li), on native or prosthetic valve, referred for 18F-FDG PET/CT from Cardiology and Infectious Diseases departments
Exclusion
- Person with a history of hypersensitivity from previous use of 68Ga-DOTATOC
- Unable to perform a 68Ga-DOTATOC PET scan (agitated, confused patient...).
- Inability to schedule 68Ga-DOTATOC PET/CT the day after 18F-FDG PET/CT.
- Person with severe renal impairment (GFR \<30 ml/min/1.73 m2)
- Participant treated with a somatostatin analogue.
- Participant with Cushing's syndrome
- Pregnant, potentially pregnant or breastfeeding women
- Adult subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
- Person of full age who is unable to give consent
- Person deprived of liberty by a judicial or administrative decision
- Person subject to psychiatric care by virtue of Articles L. 3212-1 and L. 3213-1
Key Trial Info
Start Date :
May 16 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 18 2024
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT05183555
Start Date
May 16 2022
End Date
June 18 2024
Last Update
September 26 2024
Active Locations (1)
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1
CHRU de NANCY
Vandœuvre-lès-Nancy, France, 54511