Status:
RECRUITING
Correlation of Microbiome and Metabonomics With IgA Nephropathy
Lead Sponsor:
Guangdong Provincial People's Hospital
Conditions:
IgA Nephropathy
Eligibility:
All Genders
16-65 years
Brief Summary
IgAN is the most prevalent primary glomerulonephritis in China, is characterized by the deposition of IgA1 (particularly, galactose-deficient IgA1) in the glomerular mesangium. Galactosedeficient IgA1...
Detailed Description
IgAN-microbiome is an investigator-initiated，multi-center，Observational study. This study will recruit IgA nephropathy patients who have not been treated with glucocorticoids and immunosuppressants fo...
Eligibility Criteria
Inclusion
- (1) Pathological changes of IgAN were confirmed by renal biopsy (2) Age ≥16 years (3) IgA deposition caused by secondary factors such as non-purpura glomerulonephritis, liver cirrhosis, SLE, HIV infection and hepatitis B virus associated nephritis (4) No antibiotics and/or functional foods (probiotics and/or prebiotics) for at least one month prior to sampling (5) No hormone or immunosuppressant treatment in the six months prior to sampling (6) No significant changes in diet or medication for at least one month (7) No other immune or autoimmune diseases, such as systemic lupus erythematosus (8) Signed informed consent
Exclusion
- Type I or type II diabetes
- Pregnancy and menstrual period
- Mental illness and inability to assess follow-up
- Medically diagnosed intestinal diseases such as irritable bowel syndrome and inflammatory bowel disease
- Viral hepatitis or other infectious diseases
- One month before specimen collection, use laxatives including but not limited to polyethylene glycol electrolyte dispersant, enema and other laxatives
Key Trial Info
Start Date :
May 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT05190848
Start Date
May 1 2020
End Date
December 1 2025
Last Update
March 12 2025
Active Locations (5)
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1
Sun Yat-sen Memorial Hospital Sun Yat-sen university
Guangzhou, Guangdong, China
2
The Third Affiliated Hospital of Southern Medical University
Guangzhou, Guangdong, China
3
The Third Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China
4
Guangdong Provincial People's Hospital
Guanzhou, Guangdong, China