Status:
UNKNOWN
Manufacturing, Characterization and Evaluation of the Effect of Silk Fibroin Membranes, Loaded or Not With Neurotensins on Open Wounds in the Palate
Lead Sponsor:
Universidade Estadual Paulista Júlio de Mesquita Filho
Conditions:
Wound Healing
Palate; Wound
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The aim of the present study will be to manufacture and characterize silk fibroin membranes loaded or not with neurotensin and to evaluate clinical, patient-centered and immunological parameters the e...
Detailed Description
Surgical procedures for the reconstruction of gingival and peri-Implant tissues with the purpose of restoring function and aesthetics are commonly used in the dental practice. The use of free gingival...
Eligibility Criteria
Inclusion
- Patients at least 18 years old, healthy systemically, with good oral hygiene, assessed by means of a plaque index and gingival index less than 25% (O'Leary et al., 1972)
- Patients with no morphological or pathological changes in the donor palatal region;
- Patients who have an indication for extraction and with an indication to preserve the socket for future implant installation;
- The tooth included in the study, as well as the adjacent teeth, must not have loss of periodontal insertion.
Exclusion
- Patients with systemic problems (cardiovascular changes, blood dyscrasias, immunodeficiency, diabetes, among others), who contraindicate the surgical procedure;
- Patients who use medications that interfere with wound healing;
- Pregnant or lactating patients;
- Patients who present opportunistic oral lesions, mainly colonizing the palate region;
- Smoking patients;
- Patients undergoing orthodontic treatment;
- Patients already submitted to periodontal surgery in the area of interest in the present study;
- Patients with a history of allergy to any type of material used in the present study.
Key Trial Info
Start Date :
September 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2022
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT05191082
Start Date
September 1 2020
End Date
July 1 2022
Last Update
January 13 2022
Active Locations (1)
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1
Mauro Pedrine Santamaria and Ana Carolina Ferreira Bonafe
São José dos Campos, São Paulo, Brazil, 12245000