Status:
RECRUITING
Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression
Lead Sponsor:
San Francisco Veterans Affairs Medical Center
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward respons...
Detailed Description
Rewards play a central role in driving behavior. Reward system dysfunctions are increasingly conceptualized as transdiagnostic phenomena, relevant to many psychopathologies. The opportunity to directl...
Eligibility Criteria
Inclusion
- • Our studies require some in-person visits to our research lab, located at 42nd Ave and Clement St in San Francisco.
- Inclusion Criteria:
- All participants
- 18-65 years old
- Normal (or corrected to normal) vision
- Participants with MDD
- Meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for MDD
- Screened for TMS and MRI safety
- On a stable psychiatric medication regime for \> 1 month
- Exclusion Criteria (all participants):
- Premorbid IQ estimate \< 70
- Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive sequelae)
- Loss of consciousness \> 30 minutes or any loss of consciousness with neurological sequelae
- Major medical conditions (e.g., seizure disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology), or other physical conditions if they preclude participation in EEG, TMS, or MRI protocols (e.g. peripheral nerve damage, limb paralysis etc.)
- Substance dependence, within the past year, current (past 3 months) substance misuse, or failed urine toxicology on the day of neuroimaging sessions
- Known claustrophobia
- Pregnancy (a pregnancy urine test will be conducted to rule-out pregnancy)
- Exclusion criteria (Participants with MDD only)
- Past or present DSM-5 (SCID-5) 'Schizophrenia Spectrum or Other Psychotic Disorder' diagnosis
- Past or present DSM-5 (SCID-5) Bipolar and Related Disorders Diagnosis
- Past or present DSM-5 (SCID-5) MDD with psychotic features (mood congruent or mood incongruent)
- Past or present DSM-5 (SCID-5) Gambling Disorder
- Exclusion Criteria (HCs only)
- • DSM-5 (SCID-5) criteria for any psychiatric disorder
Exclusion
Key Trial Info
Start Date :
October 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2024
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT05194098
Start Date
October 1 2021
End Date
September 30 2024
Last Update
August 2 2024
Active Locations (1)
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1
San Francisco VA Medical Center
San Francisco, California, United States, 94121