Status:
COMPLETED
MotIoN aDaptive Deep Brain Stimulation for MSA
Lead Sponsor:
University of Oxford
Collaborating Sponsors:
Oxford University Hospitals NHS Trust
Conditions:
MSA - Multiple System Atrophy
Eligibility:
All Genders
55+ years
Phase:
NA
Brief Summary
Patients routinely undergo deep brain stimulation (DBS) for treatment of symptoms related to neurodegenerative conditions, most commonly Parkinson's disease. In the Investigator's experience, and publ...
Detailed Description
Aim and patient group: Multiple System Atrophy is a form of Parkinsonism and is a neurodegenerative condition that is characterized by gait and autonomic failure. The aim of this study is to assess t...
Eligibility Criteria
Inclusion
- Diagnosis of MSA with disabling autonomic symptoms
- \>6/12 in the autonomic subsection (Q9-12) of the UMSAR scale
- Patient willing and able to give informed consent to involvement in the study.
- Male or female aged 55 years or over
- Able to walk (to perform gait analysis)
- Have an anticipated prognosis \> 2 years
Exclusion
- Female of child-bearing age
- The patient is unwilling to participate or unable to give informed consent.
- The patient has been deemed unfit for stimulator insertion by their healthcare team i.e. surgical contraindications to DBS:
- Bleeding or coagulation disorder
- Not fit for general anaesthetic
- Unable to deal with implanted DBS system (turn on and off and recharging where applicable, although it is acceptable if a carer can do this)
- Untreated anxiety or depression
- Unable to undergo preoperative MRI (e.g. metal implants)
- Subject is currently participating in a clinical investigation that includes an active treatment arm.
Key Trial Info
Start Date :
December 3 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2025
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT05197816
Start Date
December 3 2021
End Date
August 1 2025
Last Update
November 17 2025
Active Locations (1)
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1
John Radcliffe Hospital
Oxford, Oxfordshire, United Kingdom, OX3 9DU