Status:
COMPLETED
The Role of Altered Nutrient Partitioning in Food Reward
Lead Sponsor:
Virginia Polytechnic Institute and State University
Collaborating Sponsors:
National Center for Advancing Translational Sciences (NCATS)
Conditions:
Overweight and Obesity
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
Obesity remains a public health epidemic despite substantial advances in treatment strategies and therapies in the last decade. Effective strategies to support maintenance of improved metabolic health...
Eligibility Criteria
Inclusion
- BMI between 18.5-40 kg/m2
- Not pregnant or planning to become pregnant during study participation
- Residing in the Roanoke area and/or willing/able to attend sessions at the Fralin Biomedical Research Institute
- Able to speak and write in English
- Specific to fMRI scan only: BMI between 25-35 kg/m2
Exclusion
- Current inhaled nicotine use
- History of alcohol dependence.
- Current or past diagnosis of diabetes or thyroid problems.
- Glycated hemoglobin (Hemoglobin A1C) \>5.7%
- Taking medications known to influence study measures (including antiglycemic agents, thyroid medications, sleep medications)
- Active medical or neurologic disorder.
- Recent change in body weight (gain or loss of \> 5 lbs within the past 3 months)
- Current shift work (typical pattern of work/activity overnight)
- Previous weight loss surgery
- Adherence to a special diet within the past 3 months (e.g., low-carb or ketogenic diet, exclusion of food groups/specific macronutrients, intermittent fasting, etc.)
- Allergy to any food or ingredient included in the study diets, meals, or beverages
- Currently pregnant or planning to become pregnant during study participation
- Claustrophobia
- Contraindications for MRI, including pacemaker, aneurysm clips, neurostimulators, cochlear or other implants, metal in eyes, regular work with steel, etc. (Note: This is an fMRI-specific exclusion criterion. Participants may be allowed to participate in all other study sessions and measures that do not involve fMRI.)
- Contraindications for bioelectrical impedance analysis, specifically implanted devices
Key Trial Info
Start Date :
February 23 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2023
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05200845
Start Date
February 23 2022
End Date
June 1 2023
Last Update
September 8 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Fralin Biomedical Research Institute at Virginia Tech Carilion
Roanoke, Virginia, United States, 24016