Status:
RECRUITING
Level of Physical Activity and Fear Learning
Lead Sponsor:
NYU Langone Health
Conditions:
Generalized Anxiety Disorder
Social Anxiety Disorder
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The proposed experimental study will be the first to investigate whether exercise vs. sitting enhances consolidation of extinction learning in adults with high AS and anxiety disorders, and the mechan...
Detailed Description
This is an experimental study (not a treatment study) aiming to examine the effects of acute exercise vs. sitting on fear extinction learning in a 2-day paradigm. 50 eligible (after screening) men and...
Eligibility Criteria
Inclusion
- Males and females ages 18-60
- A primary diagnosis of a DSM-5 anxiety disorder (generalized anxiety disorder, panic disorder, social anxiety disorder)
- Anxiety Sensitivity Index-3 score of ≥23 (i.e., high anxiety sensitivity)
- Able and willing to provide informed consent
Exclusion
- Lifetime Bipolar Disorder or psychosis
- Past 3 months substance use disorder or eating disorder
- Current PTSD (past PTSD \> 6 months prior to screening is allowed)
- High risk for exercise according to the Physical Activity Readiness Questionnaire and American College of Sports Medicine guidelines with excluded active medical conditions including heart conditions, lung disease, bone/joint problems, or seizures
- Women who are currently pregnant
- Acute suicide risk (active suicidal ideation with plan and intent) as indicated by a score of ≥4 on the Columbia Suicide Severity Rating Scale (C-SSRS)
- Benzodiazepine use
- Current substance abuse or positive urine toxicology screen (recreational use of marijuana is permitted based on clinical assessment on the MINI structured diagnostic interview that it does not meet criteria for cannabis use disorder)
- Stable psychiatric medications for at least 4 weeks prior to experimental procedures
Key Trial Info
Start Date :
January 31 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2025
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT05203731
Start Date
January 31 2023
End Date
June 30 2025
Last Update
April 9 2025
Active Locations (1)
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1
NYU Langone Health
New York, New York, United States, 10016