Status:
ACTIVE_NOT_RECRUITING
Adaptations of the Brain in Chronic Pain With Opioid Exposure I
Lead Sponsor:
Northwestern University
Collaborating Sponsors:
Shirley Ryan AbilityLab
National Institutes of Health (NIH)
Conditions:
Chronic Back Pain
Opioid Use
Eligibility:
All Genders
18+ years
Brief Summary
This study investigates brain reorganization and behavioral responses in chronic pain with opioid exposure in Chronic Back Pain (CBP).
Detailed Description
Chronic back pain (CBP) is the most prevalent chronic pain condition in the US. Opiates are commonly prescribed to treat CBP; as such, these patients are a primary contributor to the current opioid ep...
Eligibility Criteria
Inclusion
- History of low back pain for a minimum of 6 months daily (prior to screening), meeting the Quebec Task Force Classification System symptom categories I-III;
- Male or female, age equal or greater than 18 years, with no racial/ethnic restrictions;
- Must have a Visual Analog Scale (VAS) pain score ≥ 40 mm (of 100 mm maximum) at the baseline scanning visit (for which 0mm = no pain, and 100 mm = worst pain imaginable);
- Must be able to read and speak English and be willing to read and understand instructions as well as questionnaires;
- Must be in generally stable health;
- Must sign an informed consent document after a complete explanation of the study documenting that they understand the purpose of the study, procedures to be undertaken, possible benefits and potential risks, and are willing to participate;
- Must have, on average ≥ 4/10 units of pain intensity over the course of a 1-2 week period prior to the brain scanning visit;
- Must be willing to complete daily smartphone/computer app ratings;
- Must be on regular opioid or NSAID therapy for at least 3 months prior to randomization (for opioid and non-opioid treatment groups, respectively), which will be up to the clinical investigator's decision.
Exclusion
- Low back pain associated with any systemic signs or symptoms, e.g., fever, chills;
- Evidence of rheumatoid arthritis, ankylosing spondylitis, acute vertebral fractures,
- fibromyalgia, history of tumor in the back;
- Other comorbid chronic pain or neurological conditions;
- Involvement in litigation regarding their back pain or having a disability claim or receiving workman's compensation or seeking either as a result of back pain;
- Diagnosis of current major depression or psychiatric disorder requiring treatment, or such a diagnosis in the previous 6 months;
- Beck Depression Inventory II score of \>28;
- Use of therapeutic doses of antidepressant medications at unstable doses (i.e., tricyclic depressants,
- SSRIs, SNRIs; low doses used for sleep may be allowed);
- Significant other medical disease such as diabetes, congestive heart failure, coronary or peripheral vascular disease, chronic obstructive lung disease, or malignancy;
- Uncontrolled hypertension;
- Renal insufficiency;
- Current use of recreational drugs or history of alcohol or drug abuse;
- Any change in medication for back pain in the last 30 days;
- High dose opioid prophylaxis, as defined as \> 50mg morphine equivalent/day;
- Any medical condition that in the investigator's judgment may prevent the individual from completing the study or put the individual at undue risk;
- In the judgment of the investigator, unable or unwilling to follow protocol and instructions;
- Evidence of poor treatment compliance, in the judgment of the investigator;
- Intra-axial implants (e.g. spinal cord stimulators or pumps);
- All exclusion criteria for MR safety: any metallic implants, brain or skull abnormalities, tattoos on large body parts, and claustrophobia;
- Pregnancy, or inability to use an effective form of contraception in women of child-bearing age;
- Diabetes (type 1 or type 2);
- Lactose intolerance;
- Allergic reaction to naproxen or any NSAID;
- Any untoward reaction to l-dopa or carbidopa.
Key Trial Info
Start Date :
October 31 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2024
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT05203770
Start Date
October 31 2018
End Date
June 30 2024
Last Update
March 19 2024
Active Locations (2)
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1
Northwestern University
Chicago, Illinois, United States, 60611
2
Shirley Ryan Ability Lab
Chicago, Illinois, United States, 60611