Status:
UNKNOWN
LPR Fluorescence Pilot
Lead Sponsor:
The Functional Gut Clinic
Collaborating Sponsors:
Rosa Biotech
Conditions:
Laryngopharyngeal Reflux
Gastro Esophageal Reflux
Eligibility:
All Genders
18+ years
Brief Summary
Comparing the fluorescence signatures from mouthwash samples of patients with laryngopharyngeal reflux (LPR) and healthy volunteers.
Detailed Description
The investigators aim to test if the biosensing platform Pandra, developed by Rosa Biotech, may be suitable to distinguish patients with LPR symptoms, both with and without objective evidence of gastr...
Eligibility Criteria
Inclusion
- Healthy Volunteers
- Participant is Aged 18 or above
- Participant has capacity to understand written English
- Participant is not on regular prescription medicines
- Participant has an RSI score of 0
- Participant has a body mass index (BMI) of 18.5 - 34.9 kg/m2 (bounds included)
Exclusion
- Participant has experienced any symptoms of LPR or GORD symptoms in the past year
- Participant has taken any medication for GORD/LPR in the past year (e.g. proton pump inhibitors, h2 antagonists, over the counter antacids)
- Participant has active oral disease
- Participant has a significant medical diagnosis
- Patients with symptoms of LPR
- Inclusion Criteria:
- Participant is Aged 18 or above
- Participant has capacity to understand written English
- Participant has an RSI score of \>13
- Participant has a body mass index (BMI) of 18.5 - 34.9 kg/m2 (bounds included
- Participant has been referred for 24hr ambulatory pH-impedance monitoring
Key Trial Info
Start Date :
July 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2023
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT05204303
Start Date
July 1 2022
End Date
July 1 2023
Last Update
September 2 2022
Active Locations (1)
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1
The Functional Gut Clinic
Manchester, Greater Manchester, United Kingdom, M3 4BG