Status:
COMPLETED
The Role of Dopamine, Reward Learning and Prefrontal Activity in Expectation-induced Mood Enhancement
Lead Sponsor:
Philipps University Marburg
Conditions:
Placebo Effect on Mood Improvement
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Although placebo effects on depressive symptoms are well documented, the underlying mechanisms and moderating factors of expectation effects on mood and depression are poorly understood. Various studi...
Detailed Description
The placebo effect, i.e., raising expectations towards a successful treatment by applying an inactive substance, reportedly improves therapeutic outcomes in clinical trials. Although there is supporti...
Eligibility Criteria
Inclusion
- Right-handed
- Aged 18-60 years
- German native speaker
- Informed consent
- Normal or corrected sight
Exclusion
- Current pregnancy
- Current or history of general medical, neurological or psychological disorders, which preclude sulpiride intake
- Self-reported presence of mental disorders
- Liver, kidney, and bowel disorders
- Regular smoking
- Reported alcohol abuse
- Illegal drug intake
- Regular drug intake by prescription in the past three months
- Dreadlocks
- BMI \< 19 or \> 30
- Unremovable metal objects around the head
- Previous knowledge of Japanese characters
- Excessive caffeine intake (\> 8 cups per day)
Key Trial Info
Start Date :
December 9 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 22 2023
Estimated Enrollment :
297 Patients enrolled
Trial Details
Trial ID
NCT05208294
Start Date
December 9 2021
End Date
September 22 2023
Last Update
January 16 2024
Active Locations (1)
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1
Department of Psychology, Differential Psychology and Personality Research, Philipps-University of Marburg
Marburg, Hesse, Germany, 35032