Status:
COMPLETED
Effect of Inhalatory Sedation in Subarachnoid Hemorrhage
Lead Sponsor:
A.O.U. Città della Salute e della Scienza
Conditions:
Subarachnoid Hemorrhage
Aneurysmal Subarachnoid Hemorrhage
Eligibility:
All Genders
18-64 years
Phase:
PHASE2
Brief Summary
The aim of this study is to evaluate the effect of inhalational sedation on cerebral perfusion in patients with SAH. It will evaluate whether the administration of isofluorane, by inducing direct vas...
Eligibility Criteria
Inclusion
- Age \> 18 years old
- Diagnosis of non-traumatic SAH
- Neurological and/or systemic presentation that requires support of vital functions and sedation. This occurs for a WFNS score (World Federation of Neurosurgical Societies) ≥ 3.
- Possibility of ICP monitoring through EVD which is necessary in case of acute hydrocephalous. In case of the neurosurgeon do not indicate the positioning of the EVD, an intraparenchymal catheter will be positioned for the ICP monitoring.
- Patients with vasospasm (area of cerebral blood flow under 30% of the best value detected in the brain of the patients at the first CT scan). This exam will be performed at 2° - 3° day post event.
- Acceptance of informed consent.
Exclusion
- Documented outcomes of cerebrovascular disease
- Patients with acute heart failure related to ESA
- State of pregnancy
- Patients with CLCR \< 30 mL/min
Key Trial Info
Start Date :
June 26 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT05213832
Start Date
June 26 2020
End Date
December 31 2022
Last Update
February 7 2024
Active Locations (1)
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1
AOU Città della Salute e della Scienza - Presidio CTO
Torino, Italy, 10126