Status:
RECRUITING
The Predictive Capacity of Machine Learning Models for Progressive Kidney Disease in Individuals With Sickle Cell Anemia
Lead Sponsor:
University of Tennessee
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
University of Illinois at Chicago
Conditions:
Sickle Cell Disease
Kidney Diseases, Chronic
Eligibility:
All Genders
18-65 years
Brief Summary
This is a multicenter prospective, longitudinal cohort study which will evaluate the predictive capacity of machine learning (ML) models for progression of CKD in eligible patients for a minimum of 12...
Detailed Description
Sickle cell disease (SCD) is characterized by a vasculopathy affecting multiple end organs, with complications including ischemic stroke, pulmonary hypertension, and chronic kidney disease (CKD). Albu...
Eligibility Criteria
Inclusion
- HbSS or HbSβ0 thalassemia, 18 - 65 years old;
- non-crisis, "steady state" with no acute pain episodes requiring medical contact in preceding 4 weeks;
- ability to understand the study requirements.
Exclusion
- pregnant at enrollment;
- poorly controlled hypertension;
- long-standing diabetes with suspicion for diabetic nephropathy;
- connective tissue disease such as systemic lupus erythematosus (SLE);
- polycystic kidney disease or glomerular disease unrelated to SCD;
- stem cell transplantation;
- untreated human immunodeficiency virus (HIV), hepatitis B or C infection; h) history of cancer in last 5 years; i) End-stage renal disease (ESRD) on chronic dialysis; j) prior kidney transplantation.
Key Trial Info
Start Date :
July 5 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 31 2026
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT05214105
Start Date
July 5 2022
End Date
January 31 2026
Last Update
December 14 2023
Active Locations (3)
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1
University of Illinois at Chicago
Chicago, Illinois, United States, 60612
2
Wake Forest University
Winston-Salem, North Carolina, United States, 27109
3
The University of Tennessee Health Science Center
Memphis, Tennessee, United States, 38104