Status:
COMPLETED
A Net Ultrafiltration Challenge to Predict Preload-dependence (UF CHALLENGE)
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Acute Kidney Injury
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Hemodynamic instability episodes are a frequent complication of renal replacement therapies in critically ill patients, and their incidence is associated with worse survival. Hypovolemia, identified b...
Eligibility Criteria
Inclusion
- adult patient, aged 18 year or older
- under mechanical ventilation and continuous general anesthesia, with a positive end-expiratory pressure of 5 cmH2O or more
- with stage 3 KDIGO acute kidney injury
- treated with continuous renal replacement therapy for less than 14 days
- ongoing continuous cardiac output monitoring
- with a predicted intensive care length of stay of 24 hours or more at time of screening
Exclusion
- High arterial lactate concentration, \> 4.0 mmol/L at time of screening
- Calibrated cardiac index \< 2.0 L/min/m2 or \> 4.0 L/min/m2 at time of screening
- Positive postural change maneuver in the last 2 hours preceding screening
- Patient under extracorporeal membrane oxygenation
- Patient with active bleeding requiring emergent transfusion
- Patient under chronic maintenance dialysis or renal transplant recipient
- Acute ischemic or hemorrhagic stroke complicated with coma and requiring mechanical ventilation
- Fulminant hepatitis (acute liver injury, hepatic encephalopathy, icterus and a drop in prothrombin \< 50% in less that 15 days
- Impossible postural change maneuver
- Pregnant or lactating patient
- Imminent death
- Patient under legal protection measures as by French regulation
- Patient already enrolled in the present study
- Patient already participates in a study with protocolized net ultrafiltration, ongoing at time of screening
Key Trial Info
Start Date :
July 14 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 2 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05214729
Start Date
July 14 2022
End Date
January 2 2025
Last Update
January 28 2025
Active Locations (1)
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1
Department of Intensive Care, Croix Rousse hospital, Hospices Civils de Lyon
Lyon, France, 69004