Status:
UNKNOWN
Oral 'Breath Test' to Measure Anabolic Sensitivity in Young and Older Adults at Different Activity Levels
Lead Sponsor:
University of Toronto
Conditions:
Sedentary Behavior
Aging
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Recent work in the investigators laboratory has examined the ability of a non-invasive 13CO2 breath-test to assess differences in amino acid oxidation rates and net balance in young healthy males foll...
Detailed Description
Aging is associated with a phenomenon known as anabolic resistance, whereby individuals are less responsive to anabolic stimuli (i.e., resistance exercise, dietary protein ingestion). Mild and severe ...
Eligibility Criteria
Inclusion
- Healthy young (age: 18-35 years) or older (age: 60-80 years) adults
- Average daily step-count \>7,000/day
- BMI between normal to overweight (18.5-29.9 kg/m2)
Exclusion
- Regular use of nonsteroidal anti-inflammatory drugs (with the exception of daily low-dose aspirin)
- Use of anticoagulants
- Use of a walker, cane, or assistive walking device
- Current or recently remised cancer
- Infectious or gastrointestinal disease
- Inability to comply with study protocol (e.g., \>2,000 steps/day during Step-Reduction Phase)
- Regular tobacco use
- Self-reported illicit drug use (e.g. growth hormone, testosterone, etc.)
- Diagnosed chronic illness (e.g. type 2 diabetes, heart disease, thyroid disease)
- Pregnant
- Hormonal Replacement Therapy
Key Trial Info
Start Date :
February 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2024
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT05216809
Start Date
February 1 2022
End Date
March 1 2024
Last Update
November 9 2023
Active Locations (1)
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1
Goldring Centre for High Performance Sport at the University of Toronto
Toronto, Ontario, Canada, M5S2C9