Status:
UNKNOWN
Characteristics of LKDS and PBSS of KOA Based on the Enhancement of Inflammatory Response by TGF-β/Smad Pathway Inhibited
Lead Sponsor:
Dongzhimen Hospital, Beijing
Conditions:
Knee Osteoarthritis
Syndrome
Eligibility:
All Genders
20-80 years
Brief Summary
1. Through research and analysis, the levels of upstream and downstream factors related to TGF-β/Smad signaling pathway and inflammatory response factor related factors in serum, blood cells, articula...
Detailed Description
1. Through research and analysis, the levels of upstream and downstream factors related to TGF-β/Smad signaling pathway and inflammatory response factor related factors in serum, blood cells, articula...
Eligibility Criteria
Inclusion
- Inclusion criteria of liver and kidney deficiency syndrome and phlegm and blood stasis syndrome in knee osteoarthritis
- Age 20-80 years old, in line with the diagnostic criteria of Western medicine;
- In accordance with the diagnostic criteria of TCM syndromes, it belongs to liver and kidney deficiency syndrome and phlegm and blood stasis syndrome;
- Patients who are willing to participate in the survey and have good compliance;
- Voluntary signing of informed consent;
- Inclusion criteria of normal control group
- Age 20-80 years old.
- Patients who are willing to participate in the survey and have good compliance.
- It does not meet the diagnostic criteria of knee osteoarthritis.
- Voluntarily sign informed consent.
Exclusion
- Complications affecting joints, such as psoriasis, syphilitic neuropathy, brown yellow disease, metabolic bone disease, etc;
- There were rheumatoid arthritis and ankylosing spondylitis;
- Late disabled and incapacitated;
- Pregnant or lactating women;
- Mentally ill.
- As long as one of the above 5 articles is met, it shall be excluded.
Key Trial Info
Start Date :
December 24 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
340 Patients enrolled
Trial Details
Trial ID
NCT05218122
Start Date
December 24 2021
End Date
December 31 2024
Last Update
February 1 2022
Active Locations (1)
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1
Dongzhimen Hospital
Beijing, Beijing Municipality, China, 100700