Status:
COMPLETED
Effect of Nava on Weaning Outcome in Patients With Mechanical Ventilation
Lead Sponsor:
Southeast University, China
Collaborating Sponsors:
First Affiliated Hospital of Wannan Medical College
Conditions:
ARDS
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
This study intends to compare the effects of NAVA and PSV on weaning success rate and mechanical ventilation time in patients with tracheotomy patients through a randomized controlled study.
Detailed Description
For patients with difficult weaning, NAVA can shorten the time of mechanical ventilation, but there is no large-scale study to explore the effect of NAVA on the weaning success rate and mechanical ven...
Eligibility Criteria
Inclusion
- Tracheotomy and invasive mechanical ventilation is expected to be required for \> 48h;
- When support pressure ≤ 15 cmH2O, it can withstand pressure support ventilation (PSV) time \> 1h;
Exclusion
- Age \< 18 years or \> 85 years;
- Deep sedation.
- Severe hemodynamic instability (norepinephrine or equivalent converted dose of other vasoactive drugs \> 1ug / kg.min or map ≤ 65mmhg)
- Severe respiratory center depression, high paraplegia, neuromuscular disease;
- Esophageal obstruction, esophageal perforation, severe esophageal variceal bleeding, upper gastrointestinal surgery, diaphragmatic hernia and thoracic deformity;
- Patients with chronic respiratory diseases requiring long-term home oxygen therapy;
- Patients with severe coagulation dysfunction (INR \> 1.5, APTT \> 44s, history of leukemia);
- Severe other organ dysfunction is expected to die in a short time (7 days) or palliative treatment.
- The estimated survival time of advanced solid organ or hematological system tumors is \< 30 days
- Participate in other clinical studies within 30 days;
- Failing to sign the informed consent form;
Key Trial Info
Start Date :
October 15 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 27 2025
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT05219643
Start Date
October 15 2021
End Date
February 27 2025
Last Update
April 24 2025
Active Locations (1)
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1
Zhongda Hospital
Nanjing, Jiangsu, China, 210009