Status:
TERMINATED
Selection of Farnesoid X Receptor (FXR) Ligands on the Reactivation of Latent HIV Proviruses
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Human Immunodeficiency Virus I Infection
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The FXReservoir#1 study (NCT03618862) showed that certain FXR ligands reactivate latent viruses in the reservoir circulating in all HIV+ patients tested. These molecules appear as latency reversal age...
Eligibility Criteria
Inclusion
- Criteria relating to the population studied: patients aged 18 to 65 years old, men or women, regardless of ethnic origin.
- Nosological criteria: HIV-1 infection, documented by a complete western blot and/or a detectable viral load at the time of diagnosis, regardless of the viral subtype.
- Pathology severity and progression criteria: patients with a CD4+ count greater than 500 elements/mm3 at the last follow-up visit prior to inclusion in the study. Undetectable viral load for at least six months on stable treatment.
- Criteria relating to treatments/strategies/procedures: Current cART treatment mandatory, regardless of the combination of anti-retrovirals, effective with undetectable viral load. The number of processing lines is not limited.
- Criteria relating to regulation: Absence of opposition
Exclusion
- Criteria relating to the population studied: pregnant or breastfeeding women
- Criteria relating to contraindications to the protocol explorations:
- Acute or chronic anaemias Acute infections, fever Coagulation disorders, patients taking anticoagulants
- \- Criteria relating to regulation: Subjects placed under judicial safeguard, guardianship or curatorship Subjects participating in another research with an ongoing exclusion period.
Key Trial Info
Start Date :
April 12 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 22 2022
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT05219916
Start Date
April 12 2022
End Date
July 22 2022
Last Update
March 13 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Service des maladies infectieuses et tropicales Hôpital de la Croix Rousse
Lyon, France, 69004