Status:
ACTIVE_NOT_RECRUITING
Evaluating the Impact of Computer-assisted X-ray Diagnosis and Other Triage Tools to Optimise Xpert Orientated Community-based Active Case Finding for TB and COVID-19
Lead Sponsor:
University of Cape Town
Collaborating Sponsors:
European and Developing Countries Clinical Trials Partnership (EDCTP)
Zambart
Conditions:
Tuberculosis
COVID-19
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Tuberculosis (TB) is now the commonest cause of death in many African countries. Globally, \~35% (almost 1 in 3) of TB cases are 'missed' (remain undiagnosed or undetected). In sub-Saharan Africa, 40-...
Detailed Description
Tuberculosis (TB) is now the commonest cause of death in many African countries. Several factors drive this; however, transmission is the mechanism by which these risk factors translate into active TB...
Eligibility Criteria
Inclusion
- Participants willing to complete community-based symptom screening, finger-prick and venepuncture blood sampling, urine testing, and/or undergo TB and/or COVID-19 diagnostic testing.
- Provision of informed consent.
- Participant 18 years or above.
- HIV-positive or negative participants will be included.
Exclusion
- Inability to provide informed consent (e.g., mentally impaired).
- Participants who have completed TB treatment in the last two months, or who have self-presented to their local TB clinic and are currently being worked up for suspected TB.
- Participants already diagnosed with active TB on treatment.
- Participants unable to commit to at least a two-month follow-up.
- Female participants who are pregnant or who refuse a urine pregnancy test.
- Participants in the community who cannot access healthcare due to severe ill health or lack of access to the local clinic.
Key Trial Info
Start Date :
February 23 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
26200 Patients enrolled
Trial Details
Trial ID
NCT05220163
Start Date
February 23 2022
End Date
December 1 2025
Last Update
September 25 2025
Active Locations (3)
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1
University of Cape Town
Cape Town, Western Cape, South Africa
2
Helen Ayles
Lusaka, Zambia
3
Junior Mutsvangwa
Harare, Zimbabwe