Status:
UNKNOWN
Comparison of Crystalloid and Colloid I.V Fluid Therapy in Prevention of Paracentesis Induced Circulatory Dysfunction (PICD) and Renal Dysfunction in Patients With Decompensated Liver Cirrhosis in Egypt: a Randomized Piolet Study
Lead Sponsor:
Shady Ashraf Kassem
Conditions:
Ascites
Eligibility:
All Genders
18-70 years
Brief Summary
2.2 Aim(s) of the Research (50 words max): To Compare between crystalloid and colloid I.V fluid therapy in the prevention of paracentesis induced circulatory dysfunction (PICD) and renal dysfunction ...
Detailed Description
Background (Research Question, Available Data from the literature, Current strategy for dealing with the problem, Rationale of the research that paves the way to the aim(s) of the work). (200-250 word...
Eligibility Criteria
Inclusion
- Patients less than 70 years of age and more than 18 years, diagnosed as having liver cirrhosis with tense refractory ascites (\> 5 liters). These diagnoses are determined by clinical, biochemical, morphological, and sonographic criteria.
Exclusion
- Patients with blood pressure \< 90/60 mmHg, and or HR \> 110 b/m Patients with heart disease, pulmonary disease, alcohol consumption, pregnancy, hepatorenal syndrome Patients with hepatic encephalopathy, hepatorenal syndrome, or recent GIT haemorrage in last week Patients with spontaneous bacterial peritonitis or sepsis. Prothrombin time less than 30%, platelet count less than 30,000/mm3, serum creatinine level greater than 240 mmol/l Patients receiving any drugs that could interfere with cardiovascular, hepatic, or renal function, however, the use of diuretics and/or beta-blockers were permitted, but they were temporarily discontinued for 2 days before the investigations to eliminate the pharmacological influence on systemic vascular resistance work or volume status
Key Trial Info
Start Date :
January 11 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 11 2024
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05220891
Start Date
January 11 2023
End Date
February 11 2024
Last Update
February 2 2022
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