Status:
COMPLETED
Effect of CVP and IOH on AKI and AKD
Lead Sponsor:
Nanjing First Hospital, Nanjing Medical University
Conditions:
Acute Kidney Injury
Acute Kidney Disease
Eligibility:
All Genders
18-90 years
Brief Summary
This study was aimed to explore the effect of intraoperative venous congestion and intraoperative hypotension (IOH) on acute adverse kidney events, defined as acute kidney injury (AKI) and acute kidne...
Detailed Description
Venous congestion and IOH were primary exposures and quantified as area under the curve (AUC) of central venous pressure ≥12, 16 or 20 mmHg or mean arterial pressure ≤55, 65, 75 mmHg. The primary outc...
Eligibility Criteria
Inclusion
- Patients aged 18 years and older,
- Patients underwent cardiac surgery (coronary artery bypass grafting, heart valve surgery, heart transplant or surgical excision of intracardiac myxoma)
- Patients receiving invasive intraoperative BP monitoring during surgery
- Patients underwent cardiopulmonary bypass (CPB) during surgery
Exclusion
- Pre-existing renal insufficiency defined by presence of abnormal preoperative serum creatinine ≥ 133 μmol/L and/or preoperative diagnosis of renal insufficiency within 6 months'preoperative period.
- Patients with preoperative dialysis dependence within 60 days before the index surgical procedure,
- Surgical duration less than 30 minutes
- Surgery on the aorta
- Insufficient hemodynamic and laboratory data for outcomes and/or exposure ascertainment
Key Trial Info
Start Date :
June 1 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2021
Estimated Enrollment :
5127 Patients enrolled
Trial Details
Trial ID
NCT05222074
Start Date
June 1 2016
End Date
August 1 2021
Last Update
February 3 2022
Active Locations (1)
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1
Nanjing First Hospital
Nanjing, Jiangsu, China, 210006