Status:
COMPLETED
Optimization of PEEP During Laparoscopic Surgery
Lead Sponsor:
Karaganda Medical University
Collaborating Sponsors:
I.M. Sechenov First Moscow State Medical University
National Research Oncology and Transplantology Center, Kazakhstan
Conditions:
Post-Op Complication
Ventilator-Induced Lung Injury
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Lung-protective ventilation (LPV) during general anesthesia can trigger the development of early postoperative pulmonary complication (PPC) and ventilator associated lung injury. One of the proven com...
Detailed Description
During laparoscopic surgery pressure on alveoli increases, due to in the conditions of pneumoperitoneum, muscle relaxation, the patient's position on the operating table, excess body weight and other ...
Eligibility Criteria
Inclusion
- Patients undergoing laparoscopic surgery with mechanical lung ventilation American Society of Anesthesiologists Classification (ASA) I-III
Exclusion
- pregnancy
- age less than 18 or more than 70 years
- patients ASA \> III
- life-threatening heart rhythm abnormalities and/or systolic blood pressure \< 80 mmHg despite norepinephrine at a dose \> 2 μg/kg/min
- primary lung diseases (e.g. interstitial lung diseases, lung emphysema) or tumor metastases in the lungs
- chronic decompensated diseases with extrapulmonary organ dysfunction (tumor progression, liver cirrhosis, congestive heart failure)
- Glasgow coma score \< 14
- upper airways obstruction
Key Trial Info
Start Date :
April 14 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 26 2024
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05222893
Start Date
April 14 2021
End Date
March 26 2024
Last Update
April 12 2024
Active Locations (1)
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1
National Research Oncology and Transplantology Centre
Astana, Select, Kazakhstan, 010000