Status:
RECRUITING
Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU
Lead Sponsor:
Copenhagen University Hospital, Hvidovre
Collaborating Sponsors:
University Hospital Bispebjerg and Frederiksberg
Conditions:
Septic Shock
Hemodynamic Instability
Eligibility:
All Genders
18+ years
Brief Summary
In septic shock there is growing evidence of a state of hemodynamic "disconnection" with seemingly adequate macrocirculatory values despite actual microcirculation failing to meet cellular demand. Nor...
Eligibility Criteria
Inclusion
- Suspected or documented infection
- Need for vasopressors to maintain mean arterial blood pressure (MAP) ≥65 mmHg
- Serum lactate levels \>2 mmol/L
- Norepinephrine infusion of \> 0.2 mcg/kg/min
Exclusion
- Absolute contraindication for esophageal doppler or urinary catheter insertion as noted in the patients' charts.
- Severe valvular pathology and cardiac arrhythmias resulting in severe hemodynamic instability.
- Lithium treatment
- Treatment with other vasopressor or inotropic drugs.
Key Trial Info
Start Date :
March 8 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2025
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT05225402
Start Date
March 8 2022
End Date
December 30 2025
Last Update
March 7 2025
Active Locations (1)
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1
Hvidovre Hospital
Hvidovre, Copenhagen, Denmark, 2665