Status:

COMPLETED

Safety and Feasibility of Argatroban As Anticoagulant in Adults with ECMO

Lead Sponsor:

Medical University of Vienna

Conditions:

Extracorporeal Membrane Oxygenation Complication

Anticoagulants and Bleeding Disorders

Eligibility:

All Genders

18+ years

Phase:

PHASE2

PHASE3

Brief Summary

This prospective, randomized, controlled pilot trial aims to assess the safety and feasibility of Argatroban as an alternative anticoagulant to unfractionated heparin in patients receiving extracorpor...

Eligibility Criteria

Inclusion

  • Minimum Age 18 years
  • VV- or VA-ECMO therapy
  • Minimum of 24h planned ECMO-therapy

Exclusion

  • History of Heparin-induced thrombocytopenia (HIT)
  • High risk of bleeding, contraindication for anticoagulation (eg. active GI-bleeding, Intracerebral bleeding; Platelet count \<50G/l, congenital bleeding disorder)
  • Pregnancy
  • Severe Liver disease (SOFA score liver domain 4 points = Bilirubin \>12mg/dl)
  • Postoperative admission
  • Strong lupus anticoagulant or acquired intrinsic clotting factor deficiency at admission (APTT \>50 sec without anticoagulation).

Key Trial Info

Start Date :

December 1 2021

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

July 7 2024

Estimated Enrollment :

40 Patients enrolled

Trial Details

Trial ID

NCT05226442

Start Date

December 1 2021

End Date

July 7 2024

Last Update

September 19 2024

Active Locations (1)

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Medical University of Vienna

Vienna, Vienna, Austria, 1090