Status:
COMPLETED
Host RNA Expression Profiles and Protein Biomarkers in Neonatal Herpes Simplex Virus Infection
Lead Sponsor:
Rigshospitalet, Denmark
Collaborating Sponsors:
Statens Serum Institut
Conditions:
Neonatal Herpes Simplex Infection
Neonatal HSV Infection
Eligibility:
All Genders
Up to 28 years
Brief Summary
This study seeks to identify and test host RNA expression profiles in context to protein biomarkers in dried blood spot samples as novel diagnostic markers of neonatal herpes simplex virus infection a...
Detailed Description
Background: Herpes Simplex Virus (HSV) infection in newborns is uncommon but can be devastating and is associated with significant morbidity and mortality. The diagnosis of neonatal HSV infection is ...
Eligibility Criteria
Inclusion
- cases of newborns aged 0-28 days with verified HSV infection (positive HSV PCR in blood, cerebrospinal fluid and/or swab sample)
- controls of newborns without infection matched on gestational age, sex and birthweight
Exclusion
- dried blood spot samples that are not allowed to be used for research
- dried blood spots samples containing insufficient amount of blood for research
Key Trial Info
Start Date :
January 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 30 2022
Estimated Enrollment :
159 Patients enrolled
Trial Details
Trial ID
NCT05226949
Start Date
January 1 2022
End Date
April 30 2022
Last Update
December 28 2022
Active Locations (2)
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1
Department of Paediatrics and Adolescent Medicine, Rigshospitalet
Copenhagen, Denmark, 2100
2
Department of Congenital Disorders, Statens Serum Institut
Copenhagen, Denmark, 2300