Status:
COMPLETED
Vonoprazan Efficacy to Prevent Post Variceal Band Ligation Ulcer
Lead Sponsor:
Alexandria University
Collaborating Sponsors:
Alexandria University Hospital, Alexandria, Alexandria Governorate, Egypt
Conditions:
Portal Hypertension
Variceal Hemorrhage
Eligibility:
All Genders
18-75 years
Phase:
PHASE3
Brief Summary
Endoscopic variceal ligation (EVL) is used to control and prevent variceal bleeding in patients with liver cirrhosis, but it can be complicated by bleeding from post-EVL ulcers. the current study aims...
Detailed Description
Patients with portal hypertension who have esophageal varices usually are treated by endoscopic band ligation according to the international guidelines to prevent variceal bleeding. After band ligatio...
Eligibility Criteria
Inclusion
- Patients with liver cirrhosis with portal hypertension who are eligible for endoscopic band ligation (Bleeding varices, or non-bleeder but with risk signs) according to BAVINO VII guidelines
- Patients who completed the study protocol.
- Eligible participants who are willing to comply with the study protocol and provide written consent.
Exclusion
- Endoscopically confirmed pre-existing esophageal ulcers
- Ongoing therapy with any anti-acid agent,
- Hepatocellular carcinoma
- Portal vein thrombosis
- Previous anti-flux procedure,
- Barrett's esophagus,
- History of liver transplantation,
- Pregnancy, and allergy or past adverse reaction to acid-suppressive therapy
- Estimated glomerular filtration rate \< 60 mL/min/1.73 meter square.
Key Trial Info
Start Date :
February 15 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 15 2022
Estimated Enrollment :
284 Patients enrolled
Trial Details
Trial ID
NCT05227833
Start Date
February 15 2022
End Date
November 15 2022
Last Update
August 30 2024
Active Locations (1)
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1
Alexandria Main University Hospital
Alexandria, Alexandria Governorate, Egypt, 21521