Status:
UNKNOWN
The Influence of HIIT Versus MCT on Cardiorespiratory Fitness in PPMS
Lead Sponsor:
Klinik Valens
Collaborating Sponsors:
Technische Universität Dortmund, Germany
Conditions:
Primary Progressive Multiple Sclerosis
Exercise
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Endurance training revealed to be an effective means to increase cardiorespiratory fitness in persons with Multiple Sclerosis (MS), considered relevant to health-related quality of life in this popula...
Eligibility Criteria
Inclusion
- adult age (≥ 18 years)
- definite MS diagnosis according the 2017 revised McDonald criteria
- disease course: PPMS according to the 2013 revised Lublin criteria
- disease severity: Expanded Disability Status Scale (EDSS) score ≤ 6.0
- Informed Consent as documented by signature of participants and PI
Exclusion
- Persons suffering from severe lower extremity spasticity or severe concomitant ´ disease states (i.e., orthopaedic, cardiovascular, metabolic, psychiatric (e.g., substance abuse), other neurological, other serious medical conditions) impairing their ability to participate.
- Persons regularly performing HIIT (2-3 times per week)
- Inability to follow the procedures of the study due to language problems (i.e., participant not fluent in oral and written German language)
- Changes in disease-modifying drugs (≤ 6 weeks)
- Immunosuppressive therapy (i.e., corticosteroids) (≤ 4 weeks)
- Stem cell treatment (≤ 6 months)
- Pregnant or breast-feeding women
- Intention to become pregnant during the course of the study
- Suspected non-compliance
- Previous enrolment into the current study
- Enrolment of the investigator, his/her family members, employees, and other dependent persons
- occurrence of severe pulmonary or cardiovascular decompensations (i.e., blood pressure (Riva Rocci) \> 240/120, HR ≥ HRmax (220-years of age) (e.g. due to renal failure, hepatic dysfunction, cardiovascular disease)
- abnormalities in electrocardiography (ECG), pulse oximetry, or spirometry during initial CPET
Key Trial Info
Start Date :
May 10 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 29 2024
Estimated Enrollment :
61 Patients enrolled
Trial Details
Trial ID
NCT05229861
Start Date
May 10 2022
End Date
February 29 2024
Last Update
June 14 2022
Active Locations (1)
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1
Klinik Valens, Valens rehabilitation clinic
Valens, Canton of St. Gallen, Switzerland, 7317