Status:
WITHDRAWN
Cannabidiol Effects on Cardiovascular System and Exercise Responses
Lead Sponsor:
Castleton University
Conditions:
Healthy
Eligibility:
All Genders
18+ years
Phase:
EARLY_PHASE1
Brief Summary
To identify the autonomic effects of recreationally-relevant doses of cannabidiol (CBD) in an older population, and to evaluate the effect of CBD on exercise performance and recovery.
Detailed Description
Heart rate variability (HRV) analysis is a common method used to evaluate the function of the autonomic nervous system. While heart rate is the number of heart beats per minute, HRV is the fluctuation...
Eligibility Criteria
Inclusion
- male or female
- 18+ years (aims 3\&4)
- 50+ years (aims 1\&2)
- participants must agree to fast for 4 hours and abstain from food or beverages containing alcohol, caffeine, or CBD for 12 hours prior to each experimental session
- participants must agree to avoid exercise for 6 hours prior to each experimental session
- completion of Health History Screening Questionnaire with report indicating overall good health
- ability to comprehend and satisfactorily comply with protocol requirements
- written informed consent given prior to study participation
- low-risk for VO2max testing (aims 3\&4)
Exclusion
- women who are pregnant or lactating
- participants who have a history of adverse reactions to cannabidiol
- current medications that might influence the cardiovascular and/or autonomic systems
- any cardiac, pulmonary, renal, or metabolic disease
- walking difficulty (aims 3\&4)
- waiting for a stress test for a medical reason (aims 3\&4)
- medical contraindication to performing a treadmill stress test (aims 3\&4)
Key Trial Info
Start Date :
July 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2024
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT05232123
Start Date
July 1 2023
End Date
December 1 2024
Last Update
March 27 2024
Active Locations (1)
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1
Castleton University, Jeffords Science Building
Castleton, Vermont, United States, 05735