Status:
UNKNOWN
Vitamin D Levels and Heart Rate Variability on Endothelial Function Via RAAS Augmentation in OSA
Lead Sponsor:
University Malaysia Sarawak
Conditions:
Obstructive Sleep Apnea
Eligibility:
All Genders
18+ years
Brief Summary
The role of obstructive sleep apnea (OSA) in contributing to hyperaldosteronism, which can lead to increased morbidity and mortality, is less well-established. The vitamin D levels and sympathetic act...
Detailed Description
Obstructive sleep apnea (OSA), which is closely related to obesity, is a chronic, serious and potentially life-threatening sleep-related breathing disorder, characterized by periodic narrowing and obs...
Eligibility Criteria
Inclusion
- Aged 18 years and above
- Obese (BMI\>27.5kg/m2)
- Confirmed OSA (AHI\>5)
Exclusion
- Secondary causes of obesity, such as Cushing's syndrome or thyroid dysfunction
- Secondary hypertension, including undergone treatment for primary aldosteronism
- Chronic kidney disease (eGFR\<30ml/min/1.73m2)
- Recent myocardial infarct or stroke within 6 weeks prior to study
- Congestive heart failure
- Long-standing atrial fibrillation \>12 months
- On current CPAP use
- On vitamin D supplements
- Pregnant
Key Trial Info
Start Date :
February 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2024
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT05232201
Start Date
February 1 2022
End Date
August 1 2024
Last Update
February 9 2022
Active Locations (1)
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1
Universiti Malaysia Sarawak
Kuching, Sarawak, Malaysia, 93350