Status:
RECRUITING
Blood Pressure Variability in Non-hypertensive Patients With Ischemic Cerebrovascular Disease
Lead Sponsor:
Xuanwu Hospital, Beijing
Conditions:
Ischemic Cerebrovascular Disease
Blood Pressure Variability
Eligibility:
All Genders
18+ years
Brief Summary
This study is a single-center prospective cohort of patients with ischemic cerebrovascular disease (ICVD) who have not met the diagnostic criteria for hypertension. Ambulatory 24-hour blood pressure m...
Detailed Description
Hypertension is one of the most important risk factors of ischemic cerebrovascular disease (ICVD), while various blood pressure variability (BPV) indices are immerging as novel prognostic indicators i...
Eligibility Criteria
Inclusion
- Diagnosed as ischemic stroke or transient ischemic attack (TIA), with confirmation of computed tomography or magnetic resonance imaging.
- Less than 90 days after onset of ischemic stroke or TIA symptoms.
- The blood pressure measured 5\~90 days after the ICVD onset without any anti-hypertension treatment is less than 140/90 mmHg (an average of ≥2 readings obtained on ≥ 2 occasions after emptying bladder, relaxing for more than 5 min, and avoiding caffeine, exercise, or smoking for at least 30 min before measurement).
- Consent to participate in the study.
Exclusion
- A definite diagnosis of hypertension.
- Under anti-hypertension treatment.
- Worsening neurological conditions.
- With a National Institute of Health Stroke Scale score more than 5 points.
- Intracranial hemorrhage.
- Autonomic failure.
- With malignant tumors or poor organ functions or hematologic diseases, whose estimated life expectancy is less than 3 years.
- With contraindications to ambulatory 24-hour blood pressure monitoring or fail to finish the examination at baseline.
- Mental disease.
- Pregnant.
Key Trial Info
Start Date :
February 14 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2028
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT05232240
Start Date
February 14 2022
End Date
February 1 2028
Last Update
March 14 2022
Active Locations (1)
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1
Xuanwu Hospital, Capital Medical University
Beijing, BJ, China, 100053